Vitamin D in the perinatal period: an update

Margherita Fanos, Francesco Vierucci, Giuseppe Saggese


Vitamin D is a pleiotropic hormone modulating calcium and phosphorous metabolism. Numerous extraskeletal functions of vitamin D have been shown in recent years and the role of an adequate vitamin D status during pregnancy in terms of benefits for mother and child has been investigated. Presumed effects on pregnancy course include reduction in risk of pre-eclampsia, caesarian and preterm delivery and gestational diabetes mellitus. Short term outcomes in the offspring such as skeletal development, birthweight, and incidence of infections have also been postulated. Finally, long term effects of maternal vitamin D status during pregnancy on infant and child health would include bone health, neurodevelopment and incidence of asthma, infections and autoimmune diseases such as type 1 diabetes mellitus. As vitamin D deficiency is widespread among pregnant women all over the world, supplementation during pregnancy is a hot topic in literature, also in the light of these recent acquisitions. This review will summarize the most recent advances in this field.


vitamin D; pregnancy; newborn; infant; child; supplementation

Full Text: PDF Number of abstract views: 4409 Number of PDF views/downloads: 4879


N.B. All JPNIM articles are accessible in Open Access. You can access the page containing the full PDF article just by clicking on the “Full Text: PDF” link at the bottom of the abstract page. On the full article page, if the article doesn’t load properly in the PDF view window, please wait a few seconds or click on the “Download this PDF file” link.

Technical advice. If you are using Firefox and you are experiencing problems, please set the browser preferences as follows: Firefox > Preferences > Advanced > General > Accessibility > deselect "Warn me when web sites try to redirect or reload the page".

Privacy Policy. English text: Privacy Policy; Italian text: Privacy Policy.

Cookie Policy. English text: Cookie Policy; Italian text: Cookie Policy.